Zafar Fateen: DNA Binding and Micellar Loading of Anti-Cancer Uracil Derivatives

DNA Binding and Micellar Loading of Anti-Cancer Uracil Derivatives


Description

In the present work, characterization using electrochemical technique in conjunction with electronic spectroscopy and computational studies was done to suggest a redox mechanism and to develop a structure activity relationship. DNA binding studies showed high values of binding constant that is suggestive of uracils being more effective anticancer drugs in comparison to the clinically used drugs. In the last part of the work i.e. Drug Surfactant interaction, the strategy adopted for high drug loading of these anti cancerous drugs and sustained release capabilities of the carrier will help improve the uptake of these drugs by the tumor cells leading to a considerable improvement in the cancer treatment at the preclinical stage.

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Author: Zafar Fateen
Number of Pages: 124 pages
Published Date: 27 Mar 2013
Publisher: LAP Lambert Academic Publishing
Publication Country: none
Language: English
ISBN: 9783659349690
Download Link: Click Here
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